The companions pretty much do their own thing with or without the Sole Survivor, so it's possible to do something without the protagonist, yes.
As for where in the timeline, I'd say either during DA2 or some time after DA2, when tension between the mages and the Chantry has finally boiled over.
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The companions pretty much do their own thing with or without the Sole Survivor, so it's possible to do something without the protagonist, yes.
As for where in the timeline, I'd say either during DA2 or some time after DA2, when tension between the mages and the Chantry has finally boiled over.